Studies of neutrophil production and turnover in grey collie dogs with cyclic neutropenia
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چکیده
منابع مشابه
Studies of neutrophil production and turnover in grey collie dogs with cyclic neutropenia.
12 grey collie dogs had cyclic neutropenia with the neutropenia recurring at 11.8+/-0.1-day intervals. The recovery from neutropenia was accompanied by a single wave of myeloid proliferation, an increase in marrow myeloid-labeling indices, and an increase in serum muramidase levels. After recovery from neutropenia during the period when blood neutrophils (PMN) were normal or increased, marrow m...
متن کاملCyclic neutropenia in grey collie dogs.
By JOHN E. LUND, GEoRGE A. PADCEYF AND RIChARD L. Orr C YCLIC NEUTROPENIA is a rare hematologic disorder characterized by the chronic, cyclical recurrence of severe neutropenia which has previously 1)een described only in humans. The neutropenia recurs approximately every 21 days and lasts from 3 to 10 days. The clinical manifestations of the disease are observed during the neutropenic phase of...
متن کاملCyclic hematopoiesis: the mechanism of cyclic neutropenia in grey collie dogs.
Two grey collie dogs had regular cyclic fluctuations in the number of all formed elements of the blood. The period lengths for all elements for an individual dog were the same, but the pattern of fluctuation for each element was distinctive. Normal dogs lacked periodic fluctuations.The patterns of day-to-day variation in the normal dogs counts were consistent with a first-order autoregressive p...
متن کاملCyclic hematopoiesis in grey collie dogs: a stem-cell problem.
Studies were made to ascertain the possipetition for a limiting number of pluripoble basis of cyclic hematopoiesis in the tential stem cells with the alternating grey collie. The results of 3H-thymidine competitive pressure provided by activaand “Fe labeling in conjunction with other tion and deactivation of a neutrophil feedmarrow parameters and peripheral counts back circuit from periphery to...
متن کاملModeling complex neutrophil dynamics in the grey collie.
We have developed a mathematical model for the peripheral regulation of neutrophil production mediated by granulocyte colony-stimulating factor. We have used that model to show that the pattern of neutrophil oscillations in nine grey collies is consistent with the hypothesis that cyclical neutropenia is due to an oscillatory stem cell input to the neutrophil regulatory system, and not due to au...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1972
ISSN: 0021-9738
DOI: 10.1172/jci107026